Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk: A Cross-Sectional Study

Researchers assessed functional links between the microbiome and the plasma metabolome, cardiometabolic phenotypes and CVD risk.

Gut microbiome explained up to 11.1% and 16.4% of the variation in plasma metabolites in the population-based and obesity cohorts, respectively. Obesity-specific microbial associations were found for lipid compositions in the VLDL, IDL and LDL lipoprotein subclasses. The data also showed that plasma levels rather than fecal levels of short chain fatty acids were relevant to inflammation and CVD risk.

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