Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and lipoproteins

In this paper, circulating levels of metabolites following a meal test in individuals carrying the high risk rs790346 TT genotype (cases) and low-risk CC genotype (controls) were assessed.

Results found that TT carriers show altered postprandial triglyceride response, mainly influencing VLDL and HDL subclasses suggesting a genotype-mediated effect on hepatic lipid regulation.

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