Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

In this paper, researchers investigated associations of genetic inhibition of CETP on detailed lipoproteins using variants associated with CETP (rs247617) and HMGCR (rs12916) expression in 62,400 Europeans and detailed lipoprotein profiling. Results found that CETP inhibition does not affect size-specific

LDL cholesterol but may lower CHD risk by lowering cholesterol in other apolipoprotein-B containing lipoproteins and lowering triglyceride content of HDL particles.

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