Nightingale’s biomarker analysis service combines a lipid panel with other metabolite groups, adding value to all phases of the drug development process.
Insights into drug interventions
Tailored for drug target discovery
Nightingale delivers comprehensive biomarker services, combining a lipid panel with many other metabolite groups to provide novel molecular insights into the effect of lifestyle factors, genetic makeup and drug mechanisms. In the preclinical phase, metabolic profiling helps predict drug effects, while in clinical phases it can be used to establish personalized treatment strategies.
Metabolic profiling enhances target identification and validation, even at the preclinical stage. Combining metabolic profiling with genomics using biobank cohorts can reveal early molecular insights into drug target biology and characterize pleiotropic effects. Nightingale’s high-throughput platform can also be used to discover novel drug candidates through PheWAS approaches.
Nightingale’s metabolomics analysis platform quantifies 220+ blood biomarkers per sample (including routine lipid measurements).
Identify early response to treatment
Given Nightingale’s robust and repeatable biomarker quantification, our platform is ideal for examining metabolic effects of interventions during clinical trials. Metabolic profiling aids in drug efficacy validation and identification of side-effects.
Metabolic profiling can be used for patient stratification. Patients that are likely to benefit the most from a given treatment can be selected based on their individual metabolic signatures or early response to treatment. Our platform also enables on/off-target assessment.
Enhance postmarketing surveillance
The high-throughput of the Nightingale metabolomics platform is well suited for routine clinical practice. Metabolic profiling has been shown to improve the identification of patients at increased risk for cardiometabolic events. Combining metabolic profiles with genetic information at the individual level enables further personalization of treatment strategies.