Human genetics
October 23, 2019

Assessing the causal association of glycine with risk of cardio-metabolic diseases

Wittemans et al. Nat Commun 2019;10:1060

This study presents a meta-analysis of genome-wide association studies for glycine in more than 80,000 participants and investigates the causality between glycing and lower incidence of coronary heart disease (CHD) as well as type 2 diabetes (T2D).

Also, the study aimed to explain potential mechanisms why glycine would play an aetiological role in these incidences. Results highlight 27 loci that are associated with glycine. Findings strengthen evidence for a protective effect of glycine on CHD and show that the glycine-T2D association may be driven by a glycine-lowering effect of insulin resistance.