Jia et al. Journal of the American Heart Association 2019;8(10):e011922
In this paper, researchers used a meta-analysis approach (N=30,118) with genome-wide association study data to identify genetics determinants of circulating glycine levels.
Identified loci were then used to investigate the possible causal association between circulating glycine levels and risk of CAD and traditional risk factors. In total, 12 loci were identified for circulating glycine levels, 7 of which were novel. However, various analytical approaches with glycine-raising alleles at these loci did not provide conclusive evidence for a causal relationship between circulating glycine and risk of CAD in humans.