January 13, 2018

Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation

Wang et al. Diabetes Care 2017;40(12):1779-86

Insulin resistance has deleterious effects on cardiometabolic disease.

In this paper, researchers used Mendelian randomization analyses to clarify the causal relationships of insulin resistance (IR) on circulating blood-based metabolites. Results provide evidence evidence that IR causally affects each individual BCAA and inflammation, impling that BCAA metabolism lies on a causal pathway from adiposity and IR to type 2 diabetes.