Human genetics
March 23, 2012

Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits

Kristiansson et al. Circulation Cardiovascular Genetics 2012;5(2):242-49

Findings suggest that genes from lipid metabolism pathways have the key role in the genetic background of MetS. Researchers found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and glucose intolerance.