High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

This study uses a Bayesian model averaging (MR-BMA) to disentangle the causal role of correlated risk factors with shared genetic predictors.

They focused on identifying lipoprotein measures as mediators between lipid-associated genetic variants and coronary artery disease (CAD). Apolipoprotein B was prioritized across all datasets considered, suggesting that apolipoprotein B, is the primary lipid determinant of cardiovascular disease risk.