Circulating lipid levels were studied in relationship to age-related macular degeneration (AMD) in a large European dataset.
Nightingale's biomarker analysis platform was used to identify lipid subfraction profiles from the participants. HDL cholesterol was associated with an increased risk of AMD whereas triglycerides were associated with a decreased risk. Both were associated with drusen size, which is a common early sign of AMD. Regarding lipid subfractions, the concentration of extra-large HDL particles showed the most prominent association with AMD. Variants in lipid genes play a more ambiguous role in this association, since cholesteryl ester transfer protein risk variant (rs17231506) for AMD was in line with increased HDL levels, but lipase C risk variants (rs2043085, rs2070895) were associated in an opposite way.