Bell et al. PLoS Medicine 2018;15(8):e1002641
Mendelin Randimization study using genetic variation in age at menarche to examine whether puberty timing itself is likely to influence adiposity and cardiometabolic traits.
According to the results, puberty timing has a subtle influence on adiposity and cardiometabolic traits. Main findings support the role of puberty timing as a marker, not a driver, of adiposity and cardiometabolic trait levels. These findings further suggest that interventions to prevent adult obesity and cardiometabolic disease should focus on childhood adiposity, not puberty timing.