Drug development
January 13, 2020

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas

Liu et al. Nat Med. 2020;26;110–117

This pioneering large-scale meta-analysis from BBMRI-NL combines data from ten cohorts (n=18,873) and introduces an atlas of drug-metabolite associations for 87 commonly prescribed drugs and 150 clinically relevant plasma metabolites.

The atlas provides a tool for targeted experimental pharmaceutical research and clinical trials to improve drug efficacy and safety.