Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study

In this study, genome-wide and metabolome-wide datasets generated from large-scale cohorts were combined to investigate the causal relationship between blood metabolites and five trauma-response traits. 14 metabolites were genetically correlated with trauma-response traits.

14 metabolites were genetically correlated with trauma-response traits. In addition, polygenic risk score of four metabolites (citrate; glycoprotein acetyls; concentration of L-VLDL particles; total cholesterol in M-VLDL) was associated with the traits. Mendelian randomization analysis showed that these genetic associations were partially due to causal relationship. This study supports causal relationships between specific blood metabolites and emotional and behavioral responses to trauma experiences.