Lifestyle-intervention-induced reduction of abdominal fat is reflected by a decreased circulating glycerol level and an increased HDL diameter

This study examined the relation between lifestyle-induced changes in body composition and accompanying changes in circulating metabolic biomarkers.

Researchers used data from the Growing Old Together Study, in which 164 older adults changed their lifestyle during 13 weeks by both restricting their caloric intake and increasing physical activity. At baseline, the levels of circulating metabolic biomarkers were specifically associated with abdominal fat mass. The applied lifestyle intervention mainly reduced abdominal fat mass, and when adjusted for general weight loss, this reduction was highly associated with decreased circulating glycerol concentrations and increased HDL diameter.