In a large nested case-control study, Holmes and colleagues used Nightingale’s high-throughput NMR-based assay to quantify 225 metabolic markers, including detailed lipid and lipoprotein particle profiles, for 4662 individuals with risk of incident myocardial infarction, ischemic stroke and intracerebral hemorrhage within the China Kadoorie Biobank.

A range of associations were investigated with risk of incident vascular disease, using logistic regression adjusted for age, sex, geographical region, and environmental factors (e.g. smoking and education). Many of the associations reported are novel and inform our current understanding of atherogenic lipid profiles.