Drug development
March 23, 2016

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase

Würtz et al. Journal of the American College of Cardiology 2016;67(10):1200-10

This paper describes the detailed metabolic effects of statin therapy on lipoprotein lipids and fatty acids.

In addition to lowering LDL cholesterol, statins are found to effectively lower remnant cholesterol, along with many other lipid measures. Statins were further shown to have minimal or no side-effects on non-lipid metabolites.