Human genetics
December 26, 2015

Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol

Roman et al. American Journal of Human Genetics 2015;97(6):801-15

The paper examines the functional regulatory effects of candidate variants at the GALNT2 locus associated with high-density lipoprotein cholesterol (HDL-C) metabolism.

The study suggests that at least two regulatory variants, rs4846913 and rs2281721, might act to regulate expression of GALNT2.