Human genetics
April 2, 2018

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR, and LYPLAL1 show divergent metabolic effects

Sliz et al. Human Molecular Genetics 2018;27(12):2214–23

In this study, Nightingale’s blood biomarker analysis service was used to quantify metabolic measures (including detailed lipid and lipoprotein particle profiles), for 1,810 individuals (N fatty liver =338) from The Cardiovascular Risk in Young Finns Study.

This study illustrates how combining genetic and metabolic profiling could enhance better classification and targeted treatment of NAFLD subtypes.