Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

Researchers aimed to characterize the sex differences in CHD-relevant cardiometabolic traits at multiple life stages.

Using data from a multi-generational, the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort, they examined the mean differences by sex in over 200 circulating metabolites at fours life stages. The main findings suggest that males begin to have higher VLDL triglycerides in adolescence, and that this sex difference is larger at older ages. Higher triglyceride content may therefore be a key factor underpinning the higher age-adjusted rate of CHD among males.