Human genetics
July 23, 2018

The effect of apolipoprotein E polymorphism on serum metabolome – a population-based 10-year follow-up study

Karjalainen et al. Scientific Reports 2019:9(458)

Researchers used Nightingale's blood analysis to explore potential metabolic pathways influenced by Apolipoprotein E (apoE) polymorphisms using the population-based Young Finns Study cohort of 2,234 participants with a 10-year follow-up data.

ApoE polymorphism associated with a complex metabolic change towards atherogenic profile, including aberrations in multiple novel biomarkers related to elevated cardiometabolic and all-cause mortality risk, extending our understanding about the role of apoE in health and disease.