Our applications for ageing research

Using metabolomics to crack the code of healthy ageing

Ageing and altered metabolism go hand-in-hand

Long-living families express favorable immune-metabolic health profiles, whereas unfavorable profiles are associated with metabolic syndromes and shorter life-expectancy. Despite the strong familial contribution, a significant part of a person's average lifespan is determined by environmental exposures and lifestyle choices. Applying metabolomics to ageing research can help support identifying the optimal set of markers, including metabolic biomarkers and general health parameters, to monitor the metabolic effects. 

Nightingale's platform in ageing research

Nightingale’s comprehensive metabolomics data has been used in several studies to identify the connection between poor metabolic health and ageing. For example, our blood profile has been used to identify the impact of lifestyle choices on metabolic health and age in older populations. As poor metabolic health has also been associated with adverse health effects and chronic diseases, evidence shows the relevance of metabolic biomarker analysis in ageing research. Our platform is also suitable for studies focusing on distinct research areas, such as menopause and dementia. 

Nightingale's platform in ageing research

Nightingale’s comprehensive metabolomics data has been used in several studies to identify the connection between poor metabolic health and ageing. For example, our blood profile has been used to identify the impact of lifestyle choices on metabolic health and age in older populations. As poor metabolic health has also been associated with adverse health effects and chronic diseases, evidence shows the relevance of metabolic biomarker analysis in ageing research. Our platform is also suitable for studies focusing on distinct research areas, such as menopause and dementia. 

The next frontiers

Uncovering the molecular signature of healthy ageing is an area yet to be fully explored. As average life expectancy increases, people want to live longer while being healthy and active. Generating health scores for ageing is now possible by combining information on several lifestyle parameters, such as physical activity and nutrition, with detailed metabolic signatures.

Another exciting area to explore in more detail is inflammation. Chronic low-grade inflammation has been associated with ageing-related diseases, such as atherosclerosis, diabetes and cancers. Understanding how low-grade inflammation regulates cell damage, and vice versa, will help to support identifying modifiable metabolic risk factors, which can serve as targets for lifestyle and medical interventions.  

The next frontiers

Uncovering the molecular signature of healthy ageing is an area yet to be fully explored. As average life expectancy increases, people want to live longer while being healthy and active. Generating health scores for ageing is now possible by combining information on several lifestyle parameters, such as physical activity and nutrition, with detailed metabolic signatures.

Another exciting area to explore in more detail is inflammation. Chronic low-grade inflammation has been associated with ageing-related diseases, such as atherosclerosis, diabetes and cancers. Understanding how low-grade inflammation regulates cell damage, and vice versa, will help to support identifying modifiable metabolic risk factors, which can serve as targets for lifestyle and medical interventions.  

Related services

Our blood platform is suitable to study general health aspects and different ageing-related diseases, including the role of inflammation in ageing, neurodegenerative diseases and establishing health scores.

Contact

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