Nightingale’s comprehensive metabolic profiling provides improved molecular understanding and risk prediction of cardiovascular and metabolic diseases.
Molecular insights into health
Transforming research on population health
By measuring biomarkers from multiple pathways in one go, our metabolomics platform provides a fine-grained snapshot of systemic metabolism. This provides novel molecular insights in the effects of lifestyle factors, genetic makeup and future disease risk.
Nightingale’s biomarker analysis has been used, for example, to uncover novel biomarkers and improve the prediction of cardiovascular disease and type 2 diabetes, and is increasingly used to study many other common chronic diseases. The detailed metabolic profiling also enables the study of molecular signatures of established risk factors and effects of dietary and drug interventions. There are over 100 scientific publications applying the method.
Creating more with less
Whereas the cost structure of traditional clinical chemistry is high for broad biomarker profiling, Nightingale’s platform makes comprehensive biomarker profiling affordable for biobanks and cohorts of any scale. The platform provides over 220 biomarkers in a single experiment. Amino acids, fatty acids, glycolysis metabolites, and lipoprotein subclasses are obtained simultaneously with routine clinical lipid measures.
Over 220 biomarkers per sample with the price of routine lipids.
Indicative pricing for academia, prices exclusive of VAT
Nightingale’s NMR-based platform combines low cost with high scalability. It scales to any number of samples, providing fast delivery times. The comprehensive biomarker profiling vastly increases the value of any blood sample collection and provides financial benefits by removing the need for redundant routine measurements.
Blood sample collection
Nightingale’s analysis can acquire the biomarker measurements from any native serum or plasma which have been collected and kept according to standard procedures for lipid testing.
Automated NMR measurement
Nightingale’s biomarker platform uses NMR spectroscopy to quantify over 220 metabolic biomarker measures per blood sample with a single experiment. Amino acids, fatty acids, glycolysis metabolites, and lipoprotein subclasses are obtained simultaneously with routine clinical lipid measures.
The metabolites are quantified in absolute concentrations (e.g. mmol/l) and the biomarkers can be analysed like any other clinical chemistry data. The fully automated NMR-based biomarker quantification provides superior repeatability (CV%) compared to mass spectrometry methods and is coupled with certified quality control.
Nightingale’s biomarker analysis produces the full set of biomarkers for every sample; however, it is fully feasible to focus analyses on only individual biomarkers, single metabolic pathways, or the comprehensive metabolic profile.
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