Overview of biomarkers

The biochemical background of the deliverables can be seen at

http://www.computationalmedicine.fi/platform#metabolites:intro

Cholesterol (mmol/l)
  • VLDL cholesterol
  • LDL cholesterol
  • HDL cholesterol
  • HDL2 cholesterol
  • HDL3 cholesterol
  • Cholesterol
  • Free cholesterol
  • Esterified cholesterol
  • Remnant cholesterol

Glycerides & phospholipids (mmol/l)
  • VLDL triglycerides
  • LDL triglycerides
  • HDL triglycerides
  • Triglycerides
  • Phosphoglycerides
  • Ratio of triglycerides to phosphoglycerides
  • Phosphatidylcholine and other cholines
  • Sphingomyelins
  • Total cholines

Apolipoproteins (g/l)
  • ApoA-I
  • ApoB
  • ApoB/ApoA-I

Fatty acids and saturation
  • Total fatty acids
  • Estimated degree of unsaturation

Fatty acids (mmol/l and % of total FAs)
  • Omega-3 fatty acids
  • Omega-6 fatty acids
  • Polyunsaturated fatty acids
  • Monounsaturated fatty acids; 16:1, 18:1
  • Saturated fatty acids
  • Docosahexaenoic acid; 22:6
  • Linoleic acid; 18:2

Glycolysis related metabolites (mmol/l)
  • Glucose
  • Lactate
  • Pyruvate
  • Citrate
  • Glycerol

Amino acids (mmol/l)
  • Alanine
  • Glutamine
  • Glycine
  • Histidine

Branched-chain amino acids
  • Isoleucine
  • Leucine
  • Valine

Aromatic amino acids
  • Phenylalanine
  • Tyrosine

Ketone bodies (mmol/l)
  • Acetate
  • Acetoacetate
  • 3-hydroxybutyrate

Fluid balance
  • Creatinine (mmol/l)
  • Albumin (signal area)

Inflammation (mmol/l)
  • Glycoprotein acetyls

14 Lipoprotein subclasses, 12 lipid measures for each subclass
  • Esterified cholesterol (mmol/l and % of total lipids)
  • Free cholesterol (mmol/l and % of total lipids)
  • Triglycerides (mmol/l and % of total lipids)
  • Phospholipids (mmol/l and % of total lipids
  • Total cholesterol (mmol/l and % of total lipids)
  • Total lipids (mmol/l)
  • Particle concentration (╬╝mol/l)

Lipoprotein particle size (nm)
  • Mean diameter of VLDL particles
  • Mean diameter of LDL particles
  • Mean diameter of HDL particles