Publications

Nightingale’s biomarker analysis platform is routinely used in world-class epidemiological and genetic studies. There are over 300 publications that have applied our method. See full list of publications here.

All

Metabolic risk factors

Blood biomarker score identifies individuals at high risk for severe COVID-19 - metabolic profiling of 105,000 adults in the UK Biobank

Identification of healthy people at high risk for severe COVID-19 is a global health priority. This study investigated whether blood biomarkers measured by high-throughput metabolomics could be predictive of severe pneumonia and COVID-19 hospitalisation years after the blood sampling. Nightingale metabolomics was used to quantify a comprehensive biomarker profile in 105,146 plasma samples collected in the UK Biobank during 2007-2010 (age range 39-70).

Würtz et al. MedRxiv 2020; preprint

Bioinformatics

High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease

Zuber et al. MedRxiv 2020; preprint

Human genetics

Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

Lotta et al. BioRxiv 2020; preprint

Cardiovascular diseases

Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults

Joshi et al. Eur J Prev Cardiol. 2020; preprint

Nutrition

Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome

Coltell et al. Nutrients 2020;12(2):E310

Metabolic risk factors

Sex differences in infant blood metabolite profile in association with weight and adiposity measures

Ellul et al. Pediatr Res. 2020; preprint

Bioinformatics

EpiMetal: an open-source graphical web browser tool for easy statistical analyses in epidemiology and metabolomics

Ekholm et al. Int J Epidemiol. 2020; preprint

Cardiovascular diseases

Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics

Bell et al. MedRxiv 2020; preprint

Drug development

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas

Liu et al. Nat Med. 2020;26;110–117

Human genetics

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Hagenbeek et al. Nat Commun.2020;11(1):39

Bioinformatics

Selecting causal risk factors from high-throughput experiments using multivariable Mendelian randomization

Zuber et al.Nat Commun. 2020;11(1):29

Cardiovascular diseases

Lipoprotein Signatures of Cholesteryl Ester Transfer Protein and HMG-CoA Reductase Inhibition

Kettunen et al. PLoS Biology 2019;17(12):e3000572

Cardiovascular diseases

Data-driven multivariate population subgrouping via lipoprotein phenotypes versus apolipoprotein B in the risk assessment of coronary heart disease

Ohukainen et al. Atherosclerosis 2020; preprint

Metabolic risk factors

Structure–function relationships of HDL in diabetes and coronary heart disease

Cardner et al. JCI Insight 2019; preprint

Human genetics

Investigating Causality Between Blood Metabolites and Emotional and Behavioral Responses to Traumatic Stress: a Mendelian Randomization Study

Carvalho et al. Mol Neurobiol. 2019; preprint

T2D

Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study

Wang et al. BMC Medicine 2019;17(1):217

T2D

Short-term treatment with high dose liraglutide improves lipid and lipoprotein profile and changes hormonal mediators of lipid metabolism in obese patients with no overt type 2 diabetes mellitus: a randomized, placebo-controlled, cross-over, double-blind clinical trial

Peradze et al. Cardiovasc Diabetol. 2019;18(1):141

For individuals

For business

Nightingale for business

Health initiatives

For investors

Investor pages

Nightingale as an investment

Financial information

Share and shareholders

Governance

Investor relations

Releases

Reports and presentations

IPO

Suomeksi

For research

Nightingale's research services

About us

Get our newsletter

Interested in getting the latest news about Nightingale? Subscribe to our newsletter.

Nightingale Health Oyj

Mannerheimintie 164a, 00300 Helsinki, Finland

Contact →